Drug intelligence / Profile preview

[68Ga]Ga-DOTA-(2P-PEG0)

Development stage: Preclinical
Lead developer: Soochow University
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

[68Ga]Ga-DOTA-(2P-PEG0) is a Gallium-68 labeled radiopharmaceutical designed for positron emission tomography (PET) imaging of prostate cancer. It is a dimeric molecular probe that targets the prostate-specific membrane antigen (PSMA), which is highly expressed in prostate cancer cells. The structure consists of a DOTA chelator for Gallium-68 coordination, linked to two PSMA-targeting motifs (2P) without a polyethylene glycol (PEG) spacer (PEG0). In comparative studies, this dimer was evaluated alongside PEGylated versions to determine the impact of multivalent effects and PEGylation on tumor accumulation, pharmacokinetics, and kidney clearance. It serves as a diagnostic tool to visualize and stage prostate cancer lesions.

Other names: 68Ga-DOTA-(2P-PEG0)Ga-68 DOTA-(2P-PEG0)

Targets

PSMA (Prostate-specific membrane antigen)

Beyond the preview

Go deeper on [68Ga]Ga-DOTA-(2P-PEG0).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on [68Ga]Ga-DOTA-(2P-PEG0).

Explore the full profile